It is possible to prevent cancer by getting rid of excess weight
Studies carried out in the USA in 2007; General Surgery Specialist Op. Dr. Levent Eminoglu; states that the relationship between obesity and cancer has been proven and warns. Obesity is the most important health problem of today. A very rapid increase has been observed in the last twenty years, especially in developed countries. It is a well-known fact that obesity, that is, excess weight, causes heart disease, stroke, high blood pressure, diabetes, joint diseases and some other chronic diseases. However, another risk that is not well known is the increased risk of cancer with obesity.
Excess weight causes a significant increase in the risk of esophagus, breast (post-menopausal), uterus, large intestine and rectum, kidney, pancreas, thyroid, gall bladder. Studies conducted in the USA reveal that 34,000 (4%) cancer cases in men and 50,500 (7%) cancer cases in women are caused by obesity. Although the rates of cancer attributed to obesity vary in terms of organs, It rises up to 40% in the inner surface of the uterus and esophagus.
Forecasts for 2030 show that obesity will lead to 500,000 cancer cases in the USA. If each adult achieves a 1% decrease in body mass index, which is equivalent to approximately 1 kilogram in an adult of normal height, it is calculated that this can prevent 100,000 cancers per year. Therefore, obesity; In addition to all the other problems and diseases it causes, it is the most important health problem of our time due to the increase in the risk of cancer.
Why does obesity increase the risk of cancer?
The increased adipose tissue produces an excess of estrogen. It is known that high estrogen causes an increase in breast and uterine cancers. Obese people have high levels of insulin and insulin-like growth factor 1 (IGF 1) in their blood. This condition is known as insulin resistance among the people, and it is thought to increase the development of some cancers.
Fat cells produce hormones called adipokines that increase or inhibit cell growth. For example, while leptin, which is high in overweight people, stimulates cell growth, adiponectin prevents cell proliferation. It is known that fat cells are effective on some other growth regulatory factors (mammalian target of rapamycin m TOR and AMP activated protein kinase).
What is known about the link between breast cancer and obesity?
Many studies have shown a link between breast cancer and obesity. Obesity leads to an increase in breast cancer, especially after menopause. This increase is thought to be due to high levels of estrogen. When the ovaries stop producing hormones after menopause, the most important estrogen source in the female body becomes adipose tissue. Excess adipose tissue in obese women also causes estrogen levels to remain high. Thus, estrogen-sensitive tumors are triggered.
What is known about the connection between breast cancer and endometrium?
Endometrial cancer is four times more common in overweight women, regardless of menopause. Studies specifically point to the risk of postmenopausal women who do not use medication and show weight gain. While no clear reason for this increased risk has been revealed, diabetes, excess estrogen and decreased activity level stand out as possible mechanisms.
Esophageal Bans and Obesity
The type of cancer called esophageal adenocarcinoma is two times more common in overweight and obese people than in normal-weight people. In this increase, the most blamed obesity and the increase in reflux. Chronic reflux causes damage to the esophageal cells and leads to cellular changes in the long term. In this case, there is a risk of esophageal cancer, which is thought to be related to the increase in reflux in obesity, since it causes an approximately 150-fold increase in cancer risk (Barrett esophagus).
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Colon Cancer and Obesity
Weight gain, especially in men, significantly increases the risk of bowel cancer. In this case, the distribution of excess weight in the body is also important. Abdominal obesity, defined as weight gain around the navel, constitutes the highest risk. The most important of the predicted mechanisms for the increased risk of bowel cancer is that insulin and insulin-dependent growth factors may trigger bowel cancer.